In this talk, Lenny Verkooijen demonstrated how oncologic care can be organized in such a way that that it is possible to learn from each patient and that randomized trials can be embedded in routine care. At the so-called innovation clinic, (new) cancer patients are systematically invited and offered broad informed consent, including consent to be randomized into (cohort) based trials. Using this approach, several innovations have been evaluated efficiently in highly generalizable trial populations, and the ones that have proven to be effective, were quickly employed in routine care.